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J Virol. 2014 Feb;88(3):1825-9. doi: 10.1128/JVI.02578-13. Epub 2013 Nov 13.

EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells.

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  • 1Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, New York, New York, USA.

Abstract

Mouse embryonic cells are unable to support the replication of Moloney murine leukemia virus (MLV). The integrated viral DNA is transcriptionally silenced, largely due to binding of host transcriptional repressors to the primer binding site (PBS) of the provirus. We have previously shown that a PBS DNA-binding repressor complex contains ZFP809 and TRIM28. Here, we identified ErbB3-binding protein 1 (EBP1) to be a novel component of the ZFP809-TRIM28 silencing complex and show that EBP1 depletion reduces PBS-mediated retroviral silencing.

PMID:
24227866
PMCID:
PMC3911593
DOI:
10.1128/JVI.02578-13
[PubMed - indexed for MEDLINE]
Free PMC Article
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