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J Pharm Sci. 2014 Jan;103(1):2-28. doi: 10.1002/jps.23760. Epub 2013 Nov 13.

Analysis of Sartans: a review.

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1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, Poznań, 60-780, Poland.

Abstract

The risk of cardiovascular diseases is closely related to hypertension, high cholesterol levels, and diabetes. When these risk factors appear together they are referred to as a metabolic syndrome. In the treatment of cardiovascular diseases, a combination of antihypertensive, hypolipemiant, and antidiabetic drugs is often applied. Diuretics (chlortalidone, hydrochlorothiazide, etc.) and angiotensin II receptors antagonist (sartans) are used to control hypertension, whereas statins (fluvastatin, simvastatin, etc.) are used to reduce cholesterol levels. This review is concerned with methods for the analysis of sartans in various matrices, such as pharmaceutical formulations, environmental and biological samples, and discusses the current status of stability studies of sartans . It also presents analytical methods for the simultaneous determination of sartans, diuretics, and statins.

KEYWORDS:

analysis; chromatography; properties; sartans; solid state; spectroscopy; stability

PMID:
24227012
DOI:
10.1002/jps.23760
[Indexed for MEDLINE]
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