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Glycobiology. 2014 Feb;24(2):179-84. doi: 10.1093/glycob/cwt097. Epub 2013 Nov 12.

Recruitment of galectin-3 during cell invasion and intracellular trafficking of Trypanosoma cruzi extracellular amastigotes.

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Laboratório de Tripanosomatídeos, Disciplina de Imunologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Amazonas - Bloco 6T sala 07, Campus Umuarama, 38400-902 Uberlândia, Minas Gerais, Brasil.


The invasion of host cells by the intracellular protozoan Trypanosoma cruzi requires interactions with host cell molecules, and the replication of the parasite requires escape from a parasitophorous vacuole into the host cell cytosol. Galectin-3, a member of β-galactosidase-binding lectin family, has numerous extracellular and intracellular functions. In this study, we investigated the role of galectin-3 during the invasion and intracellular trafficking of T. cruzi extracellular amastigotes (EAs). Endogenous galectin-3 from mouse peritoneal macrophages accumulated around the pathogen during cell invasion by EAs. In addition, galectin-3 accumulated around parasites after their escape from the parasitophorous vacuole. Thus, galectin-3 behaved as a novel marker of phagolysosome lysis during the infection of host cells by T. cruzi.


Trypanosoma cruzi; galectin-3; intracellular traffic; phagolysosome lysis

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