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Am J Clin Nutr. 2014 Jan;99(1):107-14. doi: 10.3945/ajcn.113.064691. Epub 2013 Nov 13.

Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.

Author information

1
Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, Sweden (KM and LB); the Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (AW); the School of Health and Social Studies, Dalarna University, Falun, Sweden (JÄ); the Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden (JÄ); and the Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden (HM).

Abstract

BACKGROUND:

A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.

OBJECTIVE:

The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.

DESIGN:

Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.

RESULTS:

During 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48).

CONCLUSION:

Low intakes and low serum concentrations of α-tocopherol are associated with an increased rate of fracture in elderly women and men.

PMID:
24225359
PMCID:
PMC3862449
DOI:
10.3945/ajcn.113.064691
[Indexed for MEDLINE]
Free PMC Article
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