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J Clin Invest. 1986 May;77(5):1712-5.

Infection of monocyte/macrophages by human T lymphotropic virus type III.

Abstract

Normal blood-derived monocyte/macrophages were found to be susceptible to infection in vitro by human T lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome. In addition, HTLV-III was recovered from monocyte/macrophages of patients infected with this virus. The above findings raise the possibility that HTLV-III-infected monocyte/macrophages may serve as a vehicle for the dissemination of virus to target organs and as a reservoir for viral persistence, as has been shown for other lentiviruses including visna virus and caprine arthritis encephalitis virus.

PMID:
2422213
PMCID:
PMC424579
DOI:
10.1172/JCI112491
[Indexed for MEDLINE]
Free PMC Article

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