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FEBS Lett. 2014 Jan 3;588(1):52-7. doi: 10.1016/j.febslet.2013.10.049. Epub 2013 Nov 9.

An N-terminal pro-atrial natriuretic peptide (NT-proANP) 'aggregation-prone' segment involved in isolated atrial amyloidosis.

Author information

1
Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece.
2
Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 116 35, Greece.
3
1st Department of Pathology, Medical School, University of Athens, 75 Mikras Assias, Goudi 115 27, Greece.
4
Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece. Electronic address: shamodr@biol.uoa.gr.

Abstract

Isolated atrial amyloidosis (IAA) is a common localized form of amyloid deposition within the atria of the aging heart. The main constituents of amyloid fibrils are atrial natriuretic peptide (ANP) and the N-terminal part of its precursor form (NT-proANP). An 'aggregation-prone' heptapeptide ((114)KLRALLT(120)) was located within the NT-proANP sequence. This peptide self-assembles into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, ATR FT-IR spectroscopy and Congo red staining studies reveal. Consequently, remedies/drugs designed to inhibit the aggregation tendency of this 'aggregation-prone' segment of NT-proANP may assist in prevention/treatment of IAA, congestive heart failure (CHF) or atrial fibrillation (AF).

KEYWORDS:

AF; ANP; ATR FT-IR spectroscopy; Amyloid fibril; BNP; CHF; Cardiac amyloidose; IAA; Isolated atrial amyloidosis (IAA); N-terminal pro-atrial natriuretic peptide; N-terminal pro-atrial natriuretic peptide (NT-proANP); NT-proANP; Natriuretic peptide; SSA; TTR; atrial fibrosis; atrial natriuretic peptide; attenuated total reflectance Fourier-transform spectroscopy; brain natriuretic peptide; cGMP; congestive heart failure; cyclic guanosine monophosphate; isolated atrial amyloidosis; senile systemic amyloidosis; transthyretin

PMID:
24220659
DOI:
10.1016/j.febslet.2013.10.049
[Indexed for MEDLINE]
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