Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen

Folia Biol (Praha). 1986;32(1):12-25.

Abstract

Monoclonal antibodies against several human leucocyte cell surface antigens were prepared and characterized: B2M-02, a non-cytotoxic antibody against beta-2-microglobulin; MEM-09 and MEM-40, against immunoglobulin kappa-type light chains; MEM-12, MEM-24G and MEM-32B, all against a monomorphic determinant in MHC class II antigens, presumably HLA-DR, dependent on the association of alpha and beta chains; MEM-15 and MEM-18, against a monocyte antigen of 55 kDa; MEM-28, against a 200 kDa antigen expressed on all leucocytes; MEM-31, against the T8 antigen of the cytotoxic/suppressor T-lymphocyte subpopulation; MEM-32, against the T1 antigen of T lymphocytes.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / analysis
  • Antibodies, Monoclonal / biosynthesis*
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface / analysis*
  • Antigens, Surface / immunology*
  • Chromatography, Affinity
  • Electrophoresis, Polyacrylamide Gel
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / analysis
  • Fluorescent Antibody Technique
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Hybridomas / immunology
  • Immunoglobulin kappa-Chains / immunology*
  • Leukocytes / classification
  • Leukocytes / immunology
  • Liver / immunology
  • Mice
  • Mice, Inbred BALB C / immunology
  • Monocytes / immunology*
  • T-Lymphocytes / immunology
  • Thymus Gland / immunology
  • beta 2-Microglobulin / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Epitopes
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Immunoglobulin kappa-Chains
  • beta 2-Microglobulin