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Arch Environ Occup Health. 2015;70(1):19-26. doi: 10.1080/19338244.2013.853646.

Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.

Author information

1
a Department of Epidemiology and Public Health , University of Maryland School of Medicine , Baltimore , Maryland , USA.

Abstract

This study examined the associations between pesticide exposure, genetic polymorphisms for

NAD(P)H:

quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.

KEYWORDS:

Egypt; agricultural workers; bladder cancer; epidemiology; gene polymorphism; pesticides

PMID:
24219772
PMCID:
PMC4018465
DOI:
10.1080/19338244.2013.853646
[Indexed for MEDLINE]
Free PMC Article

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