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Neuropsychology. 2014 Mar;28(2):273-80. doi: 10.1037/neu0000013. Epub 2013 Nov 11.

Memory consolidation in aging and MCI after 1 week.

Author information

1
Memory and Aging Center, Department of Neurology, University of California, San Francisco.
2
Department of Clinical Neurology, University of Oxford.

Abstract

OBJECTIVE:

To assess consolidation in amnestic mild cognitive impairment (aMCI), controlling for differences in initial learning and using a protracted delay period for recall.

METHOD:

15 individuals with aMCI were compared with 15 healthy older adult controls on a story learning task. Subjects were trained to criteria to equalize initial learning across subjects. Recall was tested at both the 30-min typically used delay and a 1-week delay used to target consolidation.

RESULTS:

Using repeated measures ANOVAs adjusted for age, we found group × time point interactions across the entire task between the final trial and 30-min delay, and again between the 30-min and 1-week delay periods, with aMCI having greater declines in recall as compared with controls. Significant group main effects were also found, with aMCI recalling less than controls.

CONCLUSION:

Consolidation was impaired in aMCI as compared with controls. Our findings indicate that aMCI-related performance typically measured at 30 min underestimates aMCI-associated memory deficits. This is the first study to isolate consolidation by controlling for initial learning differences and using a protracted delay period to target consolidation in an aMCI sample.

PMID:
24219610
PMCID:
PMC4211844
DOI:
10.1037/neu0000013
[Indexed for MEDLINE]
Free PMC Article
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