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Wei Sheng Yan Jiu. 2013 Sep;42(5):758-63.

[Effect of in utero and lactational exposure to a binary mixture of 3,3',4,4', 5-pentachlorobiphenyl (PCB126) and 2,3',4,4',5-pentachlorobiphenyl (PCB118) on reproductive function in male rat offsprings].

[Article in Chinese]

Author information

1
Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China. xucm@zjams.com.cn

Abstract

OBJECTIVE:

To examine the effects of in utero and lactational exposure to a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB126) and 2,3',4,4',5-pentachlorobiphenyl (PCB118) on reproductive function in male rat offsprings.

METHODS:

Pregnant Sprague-Dawley rats were given the mixture by gavage with 0.096, 0.96, 4.8 microg toxic equivalency (TEQ)/kg on gestational day (GD) 15. The effects of mixture on F1 rats were observed.

RESULTS:

The male offspring in the 0.96 and 4.8 microg TEQ/kg groups showed significant inhibition of body weight gain, anogenital distance (AGD) and sperm counts. Mixtures at 4.8 microg TEQ/kg significantly reduced weights of accessory sex organs, but only prostate weight reduced at 0.96 microg TEQ/kg. There were no significant differences on serum testosterone.

CONCLUSION:

The results demonstrated that in utero and lactational exposure to the mixtures of PCB126 and PCB118 affected development of male offspring and impaired adult male offspring reproductive organs.

PMID:
24218881
[Indexed for MEDLINE]
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