Motionless phase stepping in X-ray phase contrast imaging with a compact source

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19268-72. doi: 10.1073/pnas.1311053110. Epub 2013 Nov 11.

Abstract

X-ray phase contrast imaging offers a way to visualize the internal structures of an object without the need to deposit significant radiation, and thereby alleviate the main concern in X-ray diagnostic imaging procedures today. Grating-based differential phase contrast imaging techniques are compatible with compact X-ray sources, which is a key requirement for the majority of clinical X-ray modalities. However, these methods are substantially limited by the need for mechanical phase stepping. We describe an electromagnetic phase-stepping method that eliminates mechanical motion, thus removing the constraints in speed, accuracy, and flexibility. The method is broadly applicable to both projection and tomography imaging modes. The transition from mechanical to electromagnetic scanning should greatly facilitate the translation of X-ray phase contrast techniques into mainstream applications.

Keywords: CT; X-ray diffraction; radiography; retrospective phase stepping; tomosynthesis.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Electromagnetic Phenomena*
  • Microscopy, Phase-Contrast / methods*
  • Models, Theoretical
  • Radiography / methods*
  • X-Ray Diffraction