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Histol Histopathol. 2014 Jun;29(6):721-30. doi: 10.14670/HH-29.721. Epub 2013 Nov 12.

Schwannomas, benign tumors with a senescent phenotype.

Author information

1
Pathology Department, Hospital Universitari Vall d'Hebron, and Universitat Autonoma de Barcelona, Barcelona, Spain.
2
J.
3
Pathology Department, Hospital de San Pau, and Universitat Autonoma de Barcelona, Barcelona, Spain.
4
Pathology Department, Hospital Parc Taulí, Sabadell, and Universitat Autonoma de Barcelona, Barcelona, Spain.
5
Oncology Department, Hospital Universitari Vall d'Hebron, Barcelona. Spain.
6
Pathology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
7
Pathology Department, Hospital Universitari Vall d'Hebron, and Universitat Autonoma de Barcelona, Barcelona, Spain. sramon@vhebron.net.
8
Pathology Department, Hospital Universitari Vall d'Hebron, and Universitat Autonoma de Barcelona, Barcelona, Spain. cromagos@vhebron.net.

Abstract

BACKGROUND:

Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence markers in Schwannomas to demonstrate the possible role of senescence in their genesis.

METHODS:

A retrospective immunohistochemical study was done in 39 schwannoma and 18 malignant peripheral nerve sheath tumors (MPNST). Staining for p16INK4a, Ki67, p53 and CyclinD1 was performed in all the cases. Additionally, β-galactosidase staining was done in those cases in which frozen tissue was available (n=8).

RESULTS:

Higher levels of p16INK4a (p=0.0001) and lower levels of Ki67 (p=0.0001) were found in Schwannomas. Beta-galactosidase activity was positive in 5/5 Schwannomas and negative in 3/3 MPNST.

CONCLUSIONS:

Our results support the senescence nature of Schwannomas and the absence of a senescence phenotype in MPNST.

PMID:
24217963
DOI:
10.14670/HH-29.721
[Indexed for MEDLINE]
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