Format

Send to

Choose Destination
Nat Rev Neurol. 2013 Dec;9(12):708-14. doi: 10.1038/nrneurol.2013.221. Epub 2013 Nov 12.

Amyotrophic lateral sclerosis--a model of corticofugal axonal spread.

Author information

1
Clinical Neuroanatomy Section, Department of Neurology, Centre for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.

Abstract

The pathological process underlying amyotrophic lateral sclerosis (ALS) is associated with the formation of cytoplasmic inclusions consisting mainly of phosphorylated 43-kDa transactive response DNA-binding protein (pTDP-43), which plays an essential part in the pathogenesis of ALS. Preliminary evidence indicates that neuronal involvement progresses at different rates, but in a similar sequence, in different patients with ALS. This observation supports the emerging concept of prion-like propagation of abnormal proteins in noninfectious neurodegenerative diseases. Although the distance between involved regions is often considerable, the affected neurons are connected by axonal projections, indicating that physical contacts between nerve cells along axons are important for dissemination of ALS pathology. This article posits that the trajectory of the spreading pattern is consistent with the induction and dissemination of pTDP-43 pathology chiefly from cortical neuronal projections, via axonal transport, through synaptic contacts to the spinal cord and other regions of the brain.

Comment in

PMID:
24217521
PMCID:
PMC3943211
DOI:
10.1038/nrneurol.2013.221
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center