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J Infect Public Health. 2014 Mar-Apr;7(2):99-105. doi: 10.1016/j.jiph.2013.07.009. Epub 2013 Nov 9.

The first reported case of possible Haemophilus influenzae type b vaccine failure from Kuwait and literature-review.

Author information

1
Department of Microbiology, Al-Sabah Hospital, Kuwait. Electronic address: pphit1@gmail.com.
2
Department of Microbiology, Al-Sabah Hospital, Kuwait.
3
Department of Paediatrics, Al-Sabah Hospital, Kuwait.

Abstract

A 17-month-old vaccinated Kuwaiti boy presented with meningitis. The Haemophilus influenzae type b (Hib) capsular antigen was detected in his blood, CSF and urine. The microorganism failed to grow in culture. This case represents the first report of possible Hib vaccine failure from Kuwait. This report examines the possible reasons for this failure by reviewing the literature and emphasizes the need to broaden the definition of vaccine failure with the aim of optimizing the timing of the vaccine booster dose for prematurely born children and establishing continuous surveillance for Hib vaccine failure.

KEYWORDS:

Haemophilus influenzae type b meningitis; Haemophilus influenzae type b vaccine failure

PMID:
24216517
DOI:
10.1016/j.jiph.2013.07.009
[Indexed for MEDLINE]
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