The presence of antibodies against the AD2 epitope of cytomegalovirus glycoprotein B is associated with acute rejection after renal transplantation

Microbiol Immunol. 2014 Jan;58(1):72-5. doi: 10.1111/1348-0421.12112.

Abstract

The aim of this study was to evaluate the association between antibodies against cytomegalovirus (CMV) glycoprotein B (gB) and acute rejection after transplantation. Seventy-seven consecutive renal transplant recipients in a D + /R+ setting were studied. Biopsy-proven rejection occurred in 35% of the recipients. Among these recipients, 85% had antibodies against CMV gB. The rate of acute rejection was significantly higher in recipients with antibodies against gB than in those without them. Antibodies against gB can be a useful predictor of acute rejection in renal transplant recipients in a D + /R+ setting.

Keywords: acute rejection; cytomegalovirus; glycoprotein B; renal transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • Epitopes / immunology*
  • Graft Rejection / etiology*
  • Humans
  • Kidney Transplantation / adverse effects*
  • Middle Aged
  • Prognosis
  • Risk Factors
  • Viral Envelope Proteins / chemistry
  • Viral Envelope Proteins / immunology*

Substances

  • Antibodies, Viral
  • Epitopes
  • Viral Envelope Proteins
  • glycoprotein B, Simplexvirus