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Addict Biol. 2015 Jan;20(1):38-42. doi: 10.1111/adb.12106. Epub 2013 Nov 11.

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence.

Author information

1
Department of Psychiatry and Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol-dependent mice at doses which had no effect in non-dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.

KEYWORDS:

AV-411; Alcohol; MN-166; alcohol dependence; alcohol preference; alcoholism; ethanol; ibudilast; neuroimmune; phosphodiesterase

PMID:
24215262
PMCID:
PMC4017009
DOI:
10.1111/adb.12106
[Indexed for MEDLINE]
Free PMC Article
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