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Angew Chem Int Ed Engl. 2014 Jan 3;53(1):74-100. doi: 10.1002/anie.201304268. Epub 2013 Nov 8.

The cross-dehydrogenative coupling of C(sp3)-H bonds: a versatile strategy for C-C bond formations.

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1
Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada) http://cjli.mcgill.ca.

Abstract

Over the last decade, substantial research has led to the introduction of an impressive number of efficient procedures which allow the selective construction of CC bonds by directly connecting two different CH bonds under oxidative conditions. Common to these methodologies is the generation of the reactive intermediates in situ by activation of both CH bonds. This strategy was introduced by the group of Li as cross-dehydrogenative coupling (CDC) and discloses waste-minimized synthetic alternatives to classic coupling procedures which rely on the use of prefunctionalized starting materials. This Review highlights the recent progress in the field of cross-dehydrogenative C sp 3C formations and provides a comprehensive overview on existing procedures and employed methodologies.

KEYWORDS:

CC coupling; CH activation; cross-coupling; green chemistry; synthetic methods

PMID:
24214829
DOI:
10.1002/anie.201304268
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