Send to

Choose Destination
See comment in PubMed Commons below
Angew Chem Int Ed Engl. 2014 Jan 3;53(1):74-100. doi: 10.1002/anie.201304268. Epub 2013 Nov 8.

The cross-dehydrogenative coupling of C(sp3)-H bonds: a versatile strategy for C-C bond formations.

Author information

Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada)


Over the last decade, substantial research has led to the introduction of an impressive number of efficient procedures which allow the selective construction of CC bonds by directly connecting two different CH bonds under oxidative conditions. Common to these methodologies is the generation of the reactive intermediates in situ by activation of both CH bonds. This strategy was introduced by the group of Li as cross-dehydrogenative coupling (CDC) and discloses waste-minimized synthetic alternatives to classic coupling procedures which rely on the use of prefunctionalized starting materials. This Review highlights the recent progress in the field of cross-dehydrogenative C sp 3C formations and provides a comprehensive overview on existing procedures and employed methodologies.


CC coupling; CH activation; cross-coupling; green chemistry; synthetic methods

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center