Format

Send to

Choose Destination
See comment in PubMed Commons below
J Thromb Thrombolysis. 2014 Jan;37(1):32-44. doi: 10.1007/s11239-013-1006-9.

Modeling thrombin generation: plasma composition based approach.

Author information

1
Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT, USA, kbrummel@uvm.edu.

Abstract

Thrombin has multiple functions in blood coagulation and its regulation is central to maintaining the balance between hemorrhage and thrombosis. Empirical and computational methods that capture thrombin generation can provide advancements to current clinical screening of the hemostatic balance at the level of the individual. In any individual, procoagulant and anticoagulant factor levels together act to generate a unique coagulation phenotype (net balance) that is reflective of the sum of its developmental, environmental, genetic, nutritional and pharmacological influences. Defining such thrombin phenotypes may provide a means to track disease progression pre-crisis. In this review we briefly describe thrombin function, methods for assessing thrombin dynamics as a phenotypic marker, computationally derived thrombin phenotypes versus determined clinical phenotypes, the boundaries of normal range thrombin generation using plasma composition based approaches and the feasibility of these approaches for predicting risk.

PMID:
24214371
DOI:
10.1007/s11239-013-1006-9
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center