Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis

Guangyu Wu; Huating Li; Mi Zhou; Qichen Fang; Yuqian Bao; Aimin Xu; Weiping Jia

doi:10.1002/dmrr.2493

Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis

Diabetes Metab Res Rev. 2014 Sep;30(6):447-56. doi: 10.1002/dmrr.2493.

Authors

Guangyu Wu¹, Huating Li, Mi Zhou, Qichen Fang, Yuqian Bao, Aimin Xu, Weiping Jia

Affiliation

¹ Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, China; Department of Medicine, Medical School of Soochow University, Suzhou, China.

PMID: 24214285
DOI: 10.1002/dmrr.2493

Abstract

Obesity is considered to be a chronic inflammatory state in which the dysfunction of adipose tissue plays a central role. The adipokines, which are cytokines secreted by adipose tissue, are key links between obesity and related diseases such as metabolic syndrome and atherosclerosis. LCN2 and A-FABP, both of which are major adipokines predominantly produced in adipose tissue, have recently been shown to be pivotal modulators of vascular function. However, different adipokines modulate the development of atherosclerosis in distinctive manners, which are partly attributable to their unique regulatory mechanisms and functions. This review highlights recent advances in the understanding of the role of two adipokines in mediating chronic inflammation and the pathogenesis of atherosclerosis.

Keywords: adipocyte fatty acid-binding protein; atherosclerosis; lipocalin-2; obesity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acute-Phase Proteins / metabolism*
Adipokines / blood
Adipokines / metabolism*
Adipose Tissue / immunology
Adipose Tissue / metabolism
Animals
Atherosclerosis / etiology*
Atherosclerosis / immunology
Atherosclerosis / metabolism
Atherosclerosis / prevention & control
Biomarkers / blood
Biomarkers / metabolism
Endothelium, Vascular / immunology
Endothelium, Vascular / physiopathology
Evidence-Based Medicine*
Fatty Acid-Binding Proteins / blood
Fatty Acid-Binding Proteins / metabolism*
Humans
Lipocalin-2
Lipocalins / blood
Lipocalins / metabolism*
Models, Biological*
Obesity / immunology
Obesity / metabolism
Obesity / physiopathology*
Obesity / therapy
Proto-Oncogene Proteins / blood
Proto-Oncogene Proteins / metabolism*

Substances

Acute-Phase Proteins
Adipokines
Biomarkers
FABP4 protein, human
Fatty Acid-Binding Proteins
LCN2 protein, human
Lipocalin-2
Lipocalins
Proto-Oncogene Proteins