Format

Send to

Choose Destination
See comment in PubMed Commons below
Nucleus. 2013 Nov-Dec;4(6):460-77. doi: 10.4161/nucl.26872. Epub 2013 Nov 8.

Tissue specificity in the nuclear envelope supports its functional complexity.

Author information

1
Wellcome Trust Centre for Cell Biology and Institute of Cell Biology; University of Edinburgh; Edinburgh, UK.

Abstract

Nuclear envelope links to inherited disease gave the conundrum of how mutations in near-ubiquitous proteins can yield many distinct pathologies, each focused in different tissues. One conundrum-resolving hypothesis is that tissue-specific partner proteins mediate these pathologies. Such partner proteins may have now been identified with recent proteome studies determining nuclear envelope composition in different tissues. These studies revealed that the majority of the total nuclear envelope proteins are tissue restricted in their expression. Moreover, functions have been found for a number these tissue-restricted nuclear envelope proteins that fit with mechanisms proposed to explain how the nuclear envelope could mediate disease, including defects in mechanical stability, cell cycle regulation, signaling, genome organization, gene expression, nucleocytoplasmic transport, and differentiation. The wide range of functions to which these proteins contribute is consistent with not only their involvement in tissue-specific nuclear envelope disease pathologies, but also tissue evolution.

KEYWORDS:

NET; NPC; cell cycle regulation; cytoskeleton; laminopathy; nuclear envelopathy; nuclear envelope; spatial genome organization; tissue specific

PMID:
24213376
PMCID:
PMC3925691
DOI:
10.4161/nucl.26872
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center