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Jpn J Clin Oncol. 2014 Jan;44(1):97-100. doi: 10.1093/jjco/hyt156. Epub 2013 Nov 8.

A randomized controlled trial of the conventional technique versus the no-touch isolation technique for primary tumor resection in patients with colorectal cancer: Japan Clinical Oncology Group Study JCOG1006.

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*Department of Surgery, Niigata Cancer Center Hospital, 2-15-3 Kawagishicho, Chuo-ku, Niigata City, 951-8566, Japan.


A randomized controlled trial is currently being conducted in Japan to demonstrate the superiority of the no-touch isolation technique over the conventional technique for patients with potentially curative colon and rectosigmoid cancer. The conventional technique procedure gives first priority to mobilization of the tumor-bearing segment of the colon, which is followed by central vascular ligation and ligation of other vasculature. Conversely, the no-touch isolation technique gives first priority to central vascular ligation, which is followed by mobilization of the tumor-bearing segment of the colon. A total of 850 patients will be enrolled in this trial. The primary endpoint is disease-free survival. Secondary endpoints are overall survival, relapse-free survival, liver metastasis-free survival, mode of recurrence, surgical morbidity, adverse events due to postoperative chemotherapy, serious adverse events and short-term clinical outcomes.


colorectal cancer; conventional technique; no-touch isolation technique; randomized controlled trial

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