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Nature. 1986 Mar 20-26;320(6059):232-8.

Transfer of specificity by murine alpha and beta T-cell receptor genes.

Abstract

T-cell receptor alpha- and beta-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected alpha and beta genes endowed the recipient cell with the specificity of the donor cell.

PMID:
2421164
DOI:
10.1038/320232a0
[Indexed for MEDLINE]

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