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Behav Brain Res. 2014 Apr 1;262:47-56. doi: 10.1016/j.bbr.2013.10.044. Epub 2013 Nov 6.

Temporary inhibition of dorsal or ventral hippocampus by muscimol: distinct effects on measures of innate anxiety on the elevated plus maze, but similar disruption of contextual fear conditioning.

Author information

1
School of Medical Science & Laboratory Medicine, JiangSu University, #301 Xue Fu Road, Zhenjiang 212013, Jiangsu Province, PR China. Electronic address: weiningzhang99@gmail.com.
2
School of Psychology, Neuroscience@Nottingham, Brain & Body Ctr, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
3
School of Medical Science & Laboratory Medicine, JiangSu University, #301 Xue Fu Road, Zhenjiang 212013, Jiangsu Province, PR China.
4
School of Medical Science & Laboratory Medicine, JiangSu University, #301 Xue Fu Road, Zhenjiang 212013, Jiangsu Province, PR China; Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland.

Abstract

Studies in rats, involving hippocampal lesions and hippocampal drug infusions, have implicated the hippocampus in the modulation of anxiety-related behaviors and conditioned fear. The ventral hippocampus is considered to be more important for anxiety- and fear-related behaviors than the dorsal hippocampus. In the present study, we compared the role of dorsal and ventral hippocampus in innate anxiety and classical fear conditioning in Wistar rats, examining the effects of temporary pharmacological inhibition by the GABA-A agonist muscimol (0.5 ug/0.5 ul/side) in the elevated plus maze and on fear conditioning to a tone and the conditioning context. In the elevated plus maze, dorsal and ventral hippocampal muscimol caused distinct behavioral changes. The effects of ventral hippocampal muscimol were consistent with suppression of locomotion, possibly accompanied by anxiolytic effects, whereas the pattern of changes caused by dorsal hippocampal muscimol was consistent with anxiogenic effects. In contrast, dorsal and ventral hippocampal muscimol caused similar effects in the fear conditioning experiments, disrupting contextual, but not tone, fear conditioning.

KEYWORDS:

Anxiety; Conditioned fear; Freezing; Hippocampus; Intracerebral infusion; Plus maze

PMID:
24211449
DOI:
10.1016/j.bbr.2013.10.044
[Indexed for MEDLINE]

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