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Trends Mol Med. 2014 Jan;20(1):1-7. doi: 10.1016/j.molmed.2013.10.003. Epub 2013 Nov 7.

Gating pluripotency via nuclear pores.

Author information

1
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
2
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
3
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Beijing Institute for Brain Disorders, Beijing, China. Electronic address: ghliu@ibp.ac.cn.
4
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: jqu@moon.ibp.ac.cn.
5
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: belmonte@salk.edu.

Abstract

In recent years, growing evidence has pointed to the interesting idea that pluripotency might be regulated by a nuclear-pore-coordinated network that controls the level of pluripotency factors in the nucleus. A thorough understanding of this process might improve our comprehension of cell pluripotency and differentiation during embryogenesis, as well as aiding the development of novel models for studying human diseases.

PMID:
24211182
DOI:
10.1016/j.molmed.2013.10.003
[Indexed for MEDLINE]
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