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Gen Hosp Psychiatry. 2014 Jan-Feb;36(1):95-8. doi: 10.1016/j.genhosppsych.2013.10.002. Epub 2013 Oct 9.

The prevalence of depression and anxiety disorders in patients with euthyroid Hashimoto's thyroiditis: a comparative study.

Author information

1
Department of Psychiatry, Aksehir State Hospital, Konya, Turkey. Electronic address: drmedineayhan@gmail.com.
2
Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
3
Department of Psychiatry, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.
4
Department of Internal Medicine, Division of Endocrinology, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.

Abstract

OBJECTIVE:

The aim of this study was to examine the current prevalence of major depression and anxiety disorders in patients with euthyroid Hashimoto's thyroiditis (HT) and euthyroid goiter.

METHOD:

The study sample was formed by consecutive 51 and 45 patients who were admitted to the endocrinology outpatient clinic and diagnosed with euthyroid HT and endemic/nonendemic goiter, respectively, and 68 healthy controls. Current diagnoses of psychiatric disorders were determined using the Structured Clinical Interview for DSM-IV. Beck Depression Inventory and Beck Anxiety Inventory were applied to the participants.

RESULTS:

There was a statistically significant difference among the three groups in terms of major depression (P=.001), any mood or anxiety disorder (P=.000), any depressive disorder (P=.020), any anxiety disorder (P=.016) and obsessive-compulsive disorder (OCD) (P=.013). In the HT group, the prevalence of depression (P=.000), OCD (P=.005) and panic disorder (P=.041) was significantly higher than that in the control group. In the goiter group, depression (P=.006), any depressive disorder (P=.03), and any mood or anxiety disorder (P=.000) were significantly common in comparison to the control group. No significant difference was found between the HT and goiter groups.

CONCLUSIONS:

Euthyroid HT and euthyroid goiter increase predisposition to major depression and anxiety disorders, and thyroid autoimmunity and other thyroid pathologies should be investigated in euthyroid patients with chronic and treatment-resistant complaints.

KEYWORDS:

Anxiety disorders; Autoimmune thyroiditis; Depression; Goiter; Hashimoto's thyroiditis

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