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Leuk Res. 2013 Dec;37(12):1719-25. doi: 10.1016/j.leukres.2013.09.019. Epub 2013 Sep 29.

Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway.

Author information

1
Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China. Electronic address: zhangxh100@sina.com.

Abstract

Arsenic trioxide (As2O3) can induce apoptosis in many tumors. However, the associated mechanisms are not clearly understood. We found that As2O3 significantly inhibited the proliferation of WSU-CLL cells and induced apoptosis in dose- and time-dependent manners. WSU-CLL cells treated with 2μM As2O3 showed survivin down-regulation and p53 up-regulation. Survivin siRNA combined with As2O3 further inhibited the proliferation of WSU-CLL cells. p53 inhibition by siRNA prevented the down-regulation of survivin by As2O3 and prevented the As2O3-induced cytotoxicity of WSU-CLL cells. These results suggest that As2O3 may be of therapeutic value for chronic lymphocytic leukemia.

KEYWORDS:

Apoptosis; Arsenic trioxide; P53 and CLL; Survivin; WSU-CLL

PMID:
24211095
PMCID:
PMC5310943
DOI:
10.1016/j.leukres.2013.09.019
[Indexed for MEDLINE]
Free PMC Article
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