Format

Send to

Choose Destination
See comment in PubMed Commons below
Phytochemistry. 2013 Dec;96:360-9. doi: 10.1016/j.phytochem.2013.10.005. Epub 2013 Nov 5.

Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum.

Author information

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; Graduate University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China.

Abstract

Sixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thyrsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619.

KEYWORDS:

Anti-HIV-1; Daphnane diterpenoids; Euphorbiaceae; Trigonostemon thyrsoideum; Trigothysoids A−P

PMID:
24210372
DOI:
10.1016/j.phytochem.2013.10.005
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center