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Fertil Steril. 2014 Feb;101(2):447-52. doi: 10.1016/j.fertnstert.2013.10.008. Epub 2013 Nov 5.

Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles.

Author information

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Center for Women's Reproductive Health, Columbia University, New York, New York. Electronic address:
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Los Angeles, California.



To elucidate the role of vitamin D in reproduction by examining the relationship between recipient vitamin D levels and pregnancy rates in donor-recipient IVF cycles.


Retrospective cohort study.


Academic tertiary care center.


Ninety-nine recipients of egg donation at University of Southern California Fertility.


Serum was collected from egg donor recipients before ET and was tested for vitamin D levels [25(OH)D].


Clinical pregnancy as defined by sonographic presence of a heartbeat at 7-8 weeks of gestation.


In a diverse population of 99 recipients (53% Caucasian, 20% Asian, 16% Hispanic, 7% African American), adjusted clinical pregnancy rates were lower among vitamin D-deficient recipients than among vitamin D-replete recipients (37% vs. 78%). Live-birth rates were 31% among vitamin D-deficient recipients, compared with 59% among vitamin D-replete recipients. There were no differences in adjusted clinical pregnancy and live-birth rates among recipients who were vitamin D deficient [25(OH)D<20 ng/mL] vs. among those who were vitamin D insufficient [20 ng/mL ≤ 25(OH)D<30 ng/mL].


Nonreplete vitamin D status [25(OH)D<30 ng/mL] was associated with lower pregnancy rates in recipients of egg donation. Since the oocyte donor-recipient model is able to separate the impact of vitamin D on oocyte vs. endometrium, these data suggest that the effects of vitamin D may be mediated through the endometrium.


25-hydroxyvitamin D; IVF; Vitamin D; endometrium; race; recipients of egg donation

[Indexed for MEDLINE]

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