Format

Send to

Choose Destination
See comment in PubMed Commons below
J Pediatr Surg. 2013 Nov;48(11):2214-8. doi: 10.1016/j.jpedsurg.2013.03.049.

First 24-h SNAP-II score and highest PaCO2 predict the need for ECMO in congenital diaphragmatic hernia.

Author information

1
Department of Neonatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

Abstract

BACKGROUND/PURPOSE:

Early clinical predictors for the use of ECMO in patients with congenital diaphragmatic hernia (CDH) are lacking. We sought to evaluate the first 24-h SNAP-II score and highest PaCO2 as predictors of ECMO support and in-hospital mortality in neonates with CDH.

METHODS:

Retrospective review of 47 consecutive neonates with CDH admitted to our institution from January 2007 to December 2010 was performed. Covariates of ECMO use including SNAP-II score and highest PaCO2 within the first 24 h of NICU admission were evaluated.

RESULTS:

Of the 47 infants in this study, 24 patients were supported with ECMO. The ECMO group had a higher incidence of pulmonary hypertension, higher PaCO2, and higher 24-h SNAP-II scores. Only the SNAP-II score and not highest PaCO2 predicted mortality following multivariate adjustment.

CONCLUSIONS:

The first 24-h SNAP-II score and highest PaCO2 may provide some prognostic value in identifying neonates who undergo ECMO support; however neither measure was independently associated with the use of therapy. Only the SNAP-II score was associated with in-hospital mortality following multivariate adjustment. Additional study is needed to validate these results in a larger data set.

KEYWORDS:

Congenital diaphragmatic hernia; Extracorporeal membrane oxygenation; SNAP-II score

PMID:
24210188
DOI:
10.1016/j.jpedsurg.2013.03.049
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center