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Mol Cell. 2013 Oct 24;52(2):157-8. doi: 10.1016/j.molcel.2013.10.008.

PAF makes it EZ(H2) for β-catenin transactivation.

Author information

1
F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

In this issue of Molecular Cell, Park and colleagues (Jung et al., 2013) show that PAF (PCNA-associated factor) binds to and hyperactivates transcriptional function of β-catenin in colon cancer cells by recruiting EZH2 to the coactivator complex. PAF-β-catenin and PAF-PCNA interactions are competitive, raising the question of whether β-catenin might regulate PCNA-dependent DNA replication and repair.

PMID:
24210173
PMCID:
PMC3848709
DOI:
10.1016/j.molcel.2013.10.008
[Indexed for MEDLINE]
Free PMC Article

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