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J Fr Ophtalmol. 2014 Jan;37(1):30-5. doi: 10.1016/j.jfo.2013.02.008. Epub 2013 Oct 24.

Correlation between aqueous flare and chorioretinal neovascularization in age-related macular degeneration following intravitreal bevacizumab injections.

Author information

1
Department of Ophthalmology IV, Centre hospitalier National des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. Electronic address: marie-helene.errera@orange.fr.
2
Department of Ophthalmology IV, Centre hospitalier National des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
3
Department of Pharmacy, université Pierre et Marie Curie-Paris-6, Centre hospitalier National des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.

Abstract

PURPOSE:

Prospective evaluation of aqueous flare following intravitreal bevacizumab (Avastin, Genentech Inc., San Francisco, CA, USA) injections in eyes with choroidal neovascularization due to age-related macular degeneration.

PATIENTS AND METHODS:

Sixteen eyes of eight patients were recruited. Aqueous humor flare was determined by laser flare meter every month after one intravitreal injection of 1.25mg of bevacizumab at baseline followed by a second injection at month3 (day 100±21days). Four patients received an injection at month6 (±10days), and one patient received an injection at month7.

RESULTS:

Two months after the first intravitreal bevacizumab injection, flare values decreased from 10±5.57 (mean±standard deviation) to 5.2±1.69photon count/ms (P=0.0207) and from 8.3±3.59 to 5.4±0photon counts/ms, 2months after the second injection (P=0.02).

CONCLUSION:

Significantly decreased aqueous humor flare levels were noted after repeated injections of bevacizumab.

KEYWORDS:

Age macular degeneration; Bevacizumab; Chorioretinal neovascularization; Dégénérescence maculaire liée à l’âge; Flare; Néovascularisation choriorétinienne

PMID:
24209785
DOI:
10.1016/j.jfo.2013.02.008
[Indexed for MEDLINE]
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