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Emerg Infect Dis. 2013 Nov;19(11):1766-74. doi: 10.3201/eid1911.130546.

Severe influenza-associated respiratory infection in high HIV prevalence setting, South Africa, 2009-2011.

Abstract

Data on influenza epidemiology in HIV-infected persons are limited, particularly for sub-Saharan Africa, where HIV infection is widespread. We tested respiratory and blood samples from patients with acute lower respiratory tract infections hospitalized in South Africa during 2009-2011 for viral and pneumococcal infections. Influenza was identified in 9% (1,056/11,925) of patients enrolled; among influenza case-patients, 358 (44%) of the 819 who were tested were infected with HIV. Influenza-associated acute lower respiratory tract infection incidence was 4-8 times greater for HIV-infected (186-228/100,000) than for HIV-uninfected persons (26-54/100,000). Furthermore, multivariable analysis showed HIV-infected patients were more likely to have pneumococcal co-infection; to be infected with influenza type B compared with type A; to be hospitalized for 2-7 days or >7 days; and to die from their illness. These findings indicate that HIV-infected persons are at greater risk for severe illnesses related to influenza and thus should be prioritized for influenza vaccination.

KEYWORDS:

AIDS; HIV; South Africa; adults; bacteria; children; co-infection; influenza; lower respiratory tract infection; pneumoccocus; pneumococcal; pneumonia; respiratory infections; vaccination; viruses

PMID:
24209781
PMCID:
PMC3837669
DOI:
10.3201/eid1911.130546
[Indexed for MEDLINE]
Free PMC Article

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