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Mol Cell. 2013 Nov 7;52(3):291-302. doi: 10.1016/j.molcel.2013.10.018.

The intertwined roles of transcription and repair proteins.

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1
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract

Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to repair DNA lesions that could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point to an even more direct function of DNA repair complexes as coactivators of transcription and the unexpected role of "scheduled" DNA damage/repair at gene promoters. Paradoxically, spontaneous DNA double-strand breaks also induce ectopic transcription that is essential for repair. Thus, transcription, DNA damage, and repair may be more physically and functionally intertwined than previously appreciated.

PMID:
24207023
PMCID:
PMC3919531
DOI:
10.1016/j.molcel.2013.10.018
[Indexed for MEDLINE]
Free PMC Article
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