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Neuron. 2013 Nov 20;80(4):914-9. doi: 10.1016/j.neuron.2013.08.009. Epub 2013 Oct 24.

Disruption of dorsolateral prefrontal cortex decreases model-based in favor of model-free control in humans.

Author information

1
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK. Electronic address: petersmittenaar@gmail.com.

Abstract

Human choice behavior often reflects a competition between inflexible computationally efficient control on the one hand and a slower more flexible system of control on the other. This distinction is well captured by model-free and model-based reinforcement learning algorithms. Here, studying human subjects, we show it is possible to shift the balance of control between these systems by disruption of right dorsolateral prefrontal cortex, such that participants manifest a dominance of the less optimal model-free control. In contrast, disruption of left dorsolateral prefrontal cortex impaired model-based performance only in those participants with low working memory capacity.

PMID:
24206669
PMCID:
PMC3893454
DOI:
10.1016/j.neuron.2013.08.009
[Indexed for MEDLINE]
Free PMC Article

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