Pd(II)-catalyzed C(sp2)-H hydroxylation with R2(O)P-coordinating group

Hong-Yu Zhang; Hong-Ming Yi; Gang-Wei Wang; Bin Yang; Shang-Dong Yang

doi:10.1021/ol403028a

Pd(II)-catalyzed C(sp2)-H hydroxylation with R2(O)P-coordinating group

Org Lett. 2013 Dec 20;15(24):6186-9. doi: 10.1021/ol403028a. Epub 2013 Nov 11.

Authors

Hong-Yu Zhang¹, Hong-Ming Yi, Gang-Wei Wang, Bin Yang, Shang-Dong Yang

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China , and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics , Lanzhou 730000, P. R. China.

PMID: 24206176
DOI: 10.1021/ol403028a

Abstract

A novel R2(O)P-directed Pd(II)-catalyzed C-H hydroxylation to synthesize various substituted 2'-phosphorylbiphenyl-2-ol compounds is described. Notably, the reaction operates under mild conditions and shows good functional group tolerance, high selectivity, and yield.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biphenyl Compounds / chemical synthesis*
Biphenyl Compounds / chemistry
Catalysis
Hydroxylation
Molecular Structure
Organometallic Compounds / chemistry*
Organophosphorus Compounds / chemical synthesis*
Organophosphorus Compounds / chemistry
Palladium / chemistry*

Substances

Biphenyl Compounds
Organometallic Compounds
Organophosphorus Compounds
Palladium