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AIDS Res Hum Retroviruses. 2014 Apr;30(4):384-8. doi: 10.1089/AID.2013.0228. Epub 2014 Jan 4.

Genome sequence of a novel HIV-1 circulating recombinant form (CRF57_BC) identified from Yunnan, China.

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1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention , Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China .


We identified a novel HIV-1 circulating recombinant form (designated CRF57_BC) from a total of four patients with no obvious epidemiologic linkage in western Yunnan (Dehong prefecture) in China. Two strains (09CN.YNFL37 and 10CN.DHFL17) were identified in this study. An additional two strains (341 and 1439) were found among strains reported in a previous study. CRF57_BC was composed of subtype B and subtype C, with one subtype B segment inserted into the gag region of the subtype C backbone. Subregion tree analysis showed that the B regions originated from a Thai B lineage and the C regions were from an India C lineage. The emergence of CRF57_BC may reflect the continual generation of various forms of intersubtype recombinants in western Yunnan.

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