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Biochem Biophys Res Commun. 1986 Feb 26;135(1):297-303.

Isolation and characterization of a carcinoma-associated antigen.

Abstract

GA733 is a murine IgG2a monoclonal antibody (MAb) against human gastric carcinoma and is highly tumoricidal in nude mice. The GA733 antigen is a cell surface protein with two subunits of 30,000 and 40,000 daltons. The antigen isolated by immunoaffinity chromatography consists mainly of the 30,000-dalton subunit which bears the GA733 epitope. This subunit displayed several isoelectric points between 6.9 and 7.7. Anti-colon carcinoma MAb 17-1A also detects this antigen, but probably binds to a different epitope.

PMID:
2420330
DOI:
10.1016/0006-291x(86)90976-9
[Indexed for MEDLINE]

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