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Curr Psychiatry Rep. 2013 Dec;15(12):423. doi: 10.1007/s11920-013-0423-y.

Genetics of eating disorders.

Author information

1
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Virchowstrasse 171, 45147, Essen, Germany, anke.hinney@uni-due.de.

Abstract

Disordered eating behavior is the core symptom of the complex disorders anorexia nervosa and bulimia nervosa. Twin and family studies derive high heritability estimates. Hence, substantial genetic influences on the etiology can be assumed for both. Initially, candidate gene studies pertaining to the monoaminergic neurotransmitter systems and to body weight regulation comprised the core of the genetic analyses. Unfortunately, confirmed, solid findings substantiated in meta-analyses are rare, so that eventually none of these associations is unequivocal. Thus, systematic, genome-wide approaches emerged to identify genes with no a priori evidence for their involvement in eating disorders. Genome-wide association studies have hinted to formerly unknown genetic regions. However, significant genome-wide findings have not yet been reported.

PMID:
24202964
DOI:
10.1007/s11920-013-0423-y
[Indexed for MEDLINE]

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