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Lab Chip. 2014 Jan 7;14(1):172-7. doi: 10.1039/c3lc50819f. Epub 2013 Nov 8.

Disease-on-a-chip: mimicry of tumor growth in mammary ducts.

Author information

1
Department of Basic Medical Sciences, Purdue University, 625 Harrison Street, Lynn Hall, West Lafayette, IN 47907-2026, USA. lelievre@purdue.edu jfleary@purdue.edu.

Abstract

We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces. Moreover, tumor nodules cocultured with the luminal epithelium in hemichannels display a different anticancer drug sensitivity compared to nodules cocultured with the luminal epithelium on a flat surface and to monocultures of tumor nodules. The mimicry of tumor development within the epithelial environment of mammary ducts provides a framework for the design and test of anticancer therapies.

PMID:
24202525
PMCID:
PMC3880579
DOI:
10.1039/c3lc50819f
[Indexed for MEDLINE]
Free PMC Article
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