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Prev Med. 2014 Jan;58:64-9. doi: 10.1016/j.ypmed.2013.10.020. Epub 2013 Nov 4.

The influence of regular walking at different times of day on blood lipids and inflammatory markers in sedentary patients with coronary artery disease.

Author information

1
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
2
Department of Cardiology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China.
3
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: drlswang@njmu.edu.cn.

Abstract

OBJECTIVE:

To examine the influence of walking at different times of day on lipids and inflammatory markers in sedentary patients with coronary artery disease (CAD).

METHODS:

A total of 330 patients recruited from Nanjing between September 2011 and November 2012 were randomly assigned to a control group (n=110), morning (n=110) or evening walking group (n=110). Both the walking groups were asked to walk 30 min/day or more on at least 5 days/week either in the morning or evening for 12 weeks. Lipids and inflammatory markers were measured before and after exercise intervention.

RESULTS:

Compared with baseline, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were improved in all groups. Significances were shown in the changes of fibrinogen, high sensitivity C-reactive protein (hsCRP), white blood cell (WBC) count, TC, triglycerides, LDL-C, lipoprotein(a) between groups. The evening walking group had a larger decrease in fibrinogen (0.16 ± 0.19 g/L, P<0.001), hsCRP (1.16 ± 1.07 mg/L, P<0.001), WBC count (0.76 ± 1.53·10(9)/L, P=0.004) and LDL-C (0.34 ± 0.31 mmol/L, P<0.001) than the other two groups.

CONCLUSIONS:

Our walking program successfully resulted in a favorable change in lipids and inflammatory markers. Patients in the evening walking group gained more benefits than those walking in the morning walking group. NCT01887093.

KEYWORDS:

CAD; Coronary artery disease; HDL-C; Inflammatory markers; LDL-C; Lipids; Lp(a); TC; TG; Time of day; WBC; Walking; coronary artery disease; high sensitivity C-reactive protein; high-density lipoprotein cholesterol; hsCRP; lipoprotein(a); low-density lipoprotein cholesterol; total cholesterol; triglycerides; white blood cell

PMID:
24201089
DOI:
10.1016/j.ypmed.2013.10.020
[Indexed for MEDLINE]

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