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Vaccine. 2013 Dec 17;32(1):54-61. doi: 10.1016/j.vaccine.2013.10.076. Epub 2013 Nov 6.

Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques.

Author information

1
Division of Biomedical Sciences, University of California-Riverside, Riverside, CA, USA; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR, USA. Electronic address: messaoud@ucr.edu.
2
Division of Biomedical Sciences, University of California-Riverside, Riverside, CA, USA.
3
Division of Biostatistics, Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, USA.
4
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA.
5
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA.

Abstract

We have recently shown that chronic alcohol consumption in a rhesus macaque model of ethanol self-administration significantly modulates the serum cytokine profile. In this study, we extended these observations by investigating the impact of chronic ethanol exposure on the immune response to Modified Vaccinia Ankara (MVA). All animals were vaccinated with MVA before ethanol exposure to ethanol and then again after 7 months of 22 h/day of "open-access" drinking of 4% (w/v) ethanol. Our results indicate that animals whose blood ethanol concentration (BEC) chronically exceeded 80 mg/dl had lower CD4 and CD8 T cell proliferation as well as IgG responses following MVA booster than control animals. In contrast, relatively moderate drinkers whose BEC remained below 80 mg/ml exhibited more robust MVA-specific IgG and CD8 T cell responses than controls. To begin to uncover mechanisms underlying the differences in MVA-specific responses between the three groups, we analyzed plasma cytokine levels and microRNA expression in peripheral blood mononuclear cells following MVA booster. Our findings suggest that moderate ethanol consumption results in higher levels of antiviral cytokines and an expression profile of microRNAs linked to CD8 T cell differentiation. In summary, moderate alcohol consumption enhances recall vaccine responses, whereas chronic alcohol intoxication suppresses this response.

KEYWORDS:

Antibody; Cytokine; Ethanol; MVA; Macaque; MicroRNA; T cell; Vaccine

PMID:
24200973
PMCID:
PMC3932370
DOI:
10.1016/j.vaccine.2013.10.076
[Indexed for MEDLINE]
Free PMC Article

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