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J Ginseng Res. 2013 Jul;37(3):308-49. doi: 10.5142/jgr.2013.37.308.

Anti-obesity effects of black ginseng extract in high fat diet-fed mice.

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Daedeok Bio Corporation Research and Development center, Daejeon 305-764, Korea.


Black ginseng is produced by a repeated steaming process. The aim of this study was to investigate the anti-obesity effects of black ginseng ethanol extract (BG-EE) in high fat (HF) diet-fed mice. Two groups were fed either a normal control (NC) diet or a HF diet (45% kcal fat). The other three groups were given a HF diet supplemented with 1% BG-EE, 3% BG-EE, and 5% BG-EE for 12 wk. The anti-obesity effects of the BG-EE supplement on body weight, the development of fat mass, and lipid mechanisms were assessed in obese mice. HF-induced hyperlipidemia, fat accumulation in the liver, and white adipose tissues were reduced after BG-EE supplementation. Total fecal weight and the amount of fecal fat excretion also were increased after BG-EE supplementation. These results suggest that BG-EE may be useful to ameliorate HF-induced obesity through the strong inhibition of fat digestion.


Black ginseng; High fat diet; Hyperlipidemia; Obesity; Panax ginseng

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