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Nanotechnol Sci Appl. 2008 Nov 2;1:45-65.

Gold nanoparticles: From nanomedicine to nanosensing.

Author information

1
School of Chemistry and Biochemistry, Parker H Petit Institute for Bioengineering and Bioscience, Atlanta, GA, USA.

Abstract

Because of their photo-optical distinctiveness and biocompatibility, gold nanoparticles (AuNPs) have proven to be powerful tools in various nanomedicinal and nanomedical applications. In this review article, we discuss recent advances in the application of AuNPs in diagnostic imaging, biosensing and binary cancer therapeutic techniques. We also provide an eclectic collection of AuNPs delivery strategies, including assorted classes of delivery vehicles, which are showing great promise in specific targeting of AuNPs to diseased tissues. However, successful clinical implementations of the promised applications of AuNPs are still hampered by many barriers. In particular, more still needs to be done regarding our understanding of the pharmacokinetics and toxicological profiles of AuNPs and AuNPs-conjugates.

KEYWORDS:

bioimaging; biosensing; gold nanoparticles (AuNPs); near infrared (NIR); photothermal therapy; receptor-mediated endocytosis (RME); surface plasmon resonance (SPR); surface-enhanced Raman scattering (SERS); targeted delivery

PMID:
24198460
PMCID:
PMC3781743
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