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J Clin Microbiol. 2014 Jan;52(1):324-7. doi: 10.1128/JCM.02618-13. Epub 2013 Nov 6.

Plasmid copy number and disease severity in naturally occurring ocular Chlamydia trachomatis infection.

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1
Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Abstract

The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity.

PMID:
24197878
PMCID:
PMC3911420
DOI:
10.1128/JCM.02618-13
[Indexed for MEDLINE]
Free PMC Article
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