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J Geriatr Psychiatry Neurol. 2014 Jun;27(2):77-84. doi: 10.1177/0891988713509135. Epub 2013 Nov 5.

The Relationships Between Poor Sleep Efficiency and Mild Cognitive Impairment in Parkinson Disease.

Author information

1
Parkinson's Disease Research Clinic, Aging Brain Centre, Brain & Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
2
Parkinson's Disease Research Clinic, Aging Brain Centre, Brain & Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia simonl@med.usyd.edu.au.

Abstract

BACKGROUND:

Mild cognitive impairment (MCI) and sleep disturbances are common features in Parkinson disease (PD). This study sought to investigate whether patients with MCI in PD (PD-MCI) have more pronounced sleep disturbance compared to those without PD-MCI and whether phenotypic presentations differ according to the PD-MCI subtypes.

METHODS:

A total of 95 patients with idiopathic PD (53 meeting criteria for PD-MCI and 42 who were not cognitively impaired) and 22 controls underwent neurological and neuropsychological examination. They wore actigraphy watches for 2 weeks, from which measures of nocturnal sleep efficiency were calculated.

RESULTS:

Patients with PD-MCI has significantly poorer sleep efficiency compared to those without PD-MCI. This effect was particularly apparent in those with multiple-domain PD-MCI, compared to those with single-domain PD-MCI. Furthermore, patients in the PD-MCI group had significantly more nontremor features.

CONCLUSIONS:

These data suggest that PD-MCI is associated with greater sleep disturbance and nontremor features of PD. This is further evidence for the potential role that sleep disturbance plays in the heterogeneity of PD.

KEYWORDS:

Parkinson disease; actigraphy; cognition; mild cognitive impairment; sleep

PMID:
24196660
DOI:
10.1177/0891988713509135
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