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Saudi J Gastroenterol. 2013 Nov-Dec;19(6):252-7. doi: 10.4103/1319-3767.121035.

Correlation between hepatitis B surface antigen titers and HBV DNA levels.

Author information

1
Department of Medicine, College of Medicine; Liver Disease Research Center, King Saud University, Riyadh 11461, Saudi Arabia, .

Abstract

BACKGROUND/AIM:

To assess the correlation between serum HBsAg titers and hepatitis B virus (HBV) DNA levels in patients with hepatitis B envelop antigen-negative (HBeAg -ve) HBV genotype-D (HBV/D) infection.

PATIENTS AND METHODS:

A total of 106 treatment- naïve, HBeAg -ve HBV/D patients were included; 78 in the inactive carrier (IC) state and 28 in the active hepatitis (AH) stage. HBV DNA load and HBsAg titers were tested using TaqMan real-time polymerase chain reaction (PCR) and automated chemiluminescent microparticle immunoassay, respectively.

RESULTS:

The median (range) log10 HBsAg titer was significantly lower in the IC group compared with AH group, 3.09 (-1 to -4.4) versus 3.68 (-0.77 to 5.09) IU/mL, respectively; P < 0.001. The suggested cutoff value of HBsAg titer to differentiate between the two groups was 3.79 log10 IU/mL. In addition, there was a significant positive correlation between HBsAg and HBV DNA levels in the whole cohort, AH, and IC groups (r = 0.6, P < 0.0001; r = 0.591, P = 0.001; and r = 0.243, P = 0.032, respectively).

CONCLUSION:

Serum HBsAg titers may correlate with HBV DNA in treatment-naïve HBeAg -ve HBV/D patients, and supports the use of HBsAg levels in clinical practice as a predictor of serum HBV DNA levels.

PMID:
24195978
PMCID:
PMC3958972
DOI:
10.4103/1319-3767.121035
[Indexed for MEDLINE]
Free PMC Article

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