Format

Send to

Choose Destination
Respir Res. 2013 Nov 6;14:120. doi: 10.1186/1465-9921-14-120.

Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD).

Author information

1
NHMRC Centre of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart 7000, Australia. haydn.walters@utas.edu.au.

Abstract

Small airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (so called EMT-Type-3) it may well also be the link with the development of cancer, which is closely associated with COPD and predominantly in large airways. In a recent study published in Respiratory Research, Qin Wang and colleagues investigated the role of urokinase plasminogen activator receptor (uPAR) in EMT in small airway epithelium of COPD patients. However, there are some issues with the paper which we wish to comment on.

PMID:
24195704
PMCID:
PMC4176099
DOI:
10.1186/1465-9921-14-120
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center