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Oxid Med Cell Longev. 2013;2013:184598. doi: 10.1155/2013/184598. Epub 2013 Sep 8.

The role of Nrf2: adipocyte differentiation, obesity, and insulin resistance.

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Department of Internal Medicine, Daegu Fatima Hospital, 99 Ayang-ro, Dong-gu, Daegu 701-600, Republic of Korea ; Departments of Internal Medicine and Biochemistry and Cell Biology, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, 50 Samduk-2Ga, Jung-gu, Daegu 700-721, Republic of Korea.


Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic.

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