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Medipix-based Spectral Micro-CT.

Author information

1
Department of Radiology, Division of Radiologic Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA ; Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA ; Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA.

Abstract

Since Hounsfield's Nobel Prize winning breakthrough decades ago, X-ray CT has been widely applied in the clinical and preclinical applications - producing a huge number of tomographic gray-scale images. However, these images are often insufficient to distinguish crucial differences needed for diagnosis. They have poor soft tissue contrast due to inherent photon-count issues, involving high radiation dose. By physics, the X-ray spectrum is polychromatic, and it is now feasible to obtain multi-energy, spectral, or true-color, CT images. Such spectral images promise powerful new diagnostic information. The emerging Medipix technology promises energy-sensitive, high-resolution, accurate and rapid X-ray detection. In this paper, we will review the recent progress of Medipix-based spectral micro-CT with the emphasis on the results obtained by our team. It includes the state- of-the-art Medipix detector, the system and method of a commercial MARS (Medipix All Resolution System) spectral micro-CT, and the design and color diffusion of a hybrid spectral micro-CT.

KEYWORDS:

Medipix all resolution system (MARS); Medipix detector; Multi-energy; hybrid spectral micro-CT; principle component analysis; spectral imaging; statistical iteration reconstruction

PMID:
24194631
PMCID:
PMC3815543

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