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Nat Rev Microbiol. 2013 Dec;11(12):863-75. doi: 10.1038/nrmicro3135. Epub 2013 Nov 6.

Keeping it quiet: chromatin control of gammaherpesvirus latency.

Author information

1
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

Abstract

The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) establish long-term latent infections associated with diverse human cancers. Viral oncogenesis depends on the ability of the latent viral genome to persist in host nuclei as episomes that express a restricted yet dynamic pattern of viral genes. Multiple epigenetic events control viral episome generation and maintenance. This Review highlights some of the recent findings on the role of chromatin assembly, histone and DNA modifications, and higher-order chromosome structures that enable gammaherpesviruses to establish stable latent infections that mediate viral pathogenesis.

PMID:
24192651
PMCID:
PMC4544771
DOI:
10.1038/nrmicro3135
[Indexed for MEDLINE]
Free PMC Article

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